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That will work to switch the output on and off.  You can tolerate a few ms switching time, so the slow base drives should be OK.  If you needed much faster, I'd suggest a smarter topology.

Some issues to consider:<ol>

<li>You said you want ESD protection on the output, but you haven't given it any.  Q3 will likely blow up with a proper ESD event.  At minimum, I suggest diodes to 5 V and ground.

<p><li>There will typically be 200 mV or so drop across Q3 when on, so the output won't get all the way to the 5 V supply.  Perhaps that's OK, but you need to at least consider it.

</ol>